A study of the robustness of the EGFR signalling cascade using continuous membrane systems

Title	A study of the robustness of the EGFR signalling cascade using continuous membrane systems
Publication Type	Journal Papers
Year of Publication	2005
Authors	Pérez-Jiménez, M. J., & Romero-Campero F. J.
Journal Title	Lecture Notes in Computer Science
ISBN Number	978-3-540-26298-5
Publisher	Springer
Place Published	Amsterdam, The Netherlands
Volume	3561
Pages	268-278
Abstract	Many approaches to anticancer treatment have had a limited success. A fundamental hurdle to cancer therapy is the robustness of the signalling networks involved in tumourgenesis. The complexity of networks of biological signalling pathways is such that the development of simplifying models is essential in trying to understand the wide-ranging cellular responses they can generate. In this paper a model of the epidermal growth factor receptor signalling cascade is developed using continuous membrane systems. This model is used to study the robustness of this signalling cascade which is known to play a key role in tumour cell proliferation, angiogenesis and metastasis
Keywords	EGFR signalling network, Membrane computing, robustness., signal transduction
URL	http://www.springerlink.com/content/v4huv310xm92vm10/?p=16f5fea3cb444987a8c6641261510c68&pi=27
ISSN Number	0302-9743
DOI	10.1007/b137289

Research Group on Natural Computing