Notch signalling and cellular fate choices: A short review

TitleNotch signalling and cellular fate choices: A short review
Publication TypeConference Contributions
Year of Publication2009
AuthorsHenley, B. M.
Conference Name7th Brainstorming Week on Membrane Computing
ISBN Number978-84-613-2837-6
PublisherFénix Editora
Place PublishedSevilla, España
Date Published02/02/2009

During mammalian central nervous system (CNS) development, an enor-
mous variety of cell types are generated. This cell diversity is due in part to asymmetrical
cell division. Asymmetrical segregation of Numb, a cell-determinant protein, can result
in the differential activation of the Notch pathway. The Notch pathway defines one of
the few fundamental signalling pathways that govern metazoan development. Notch sig-
nals link the fate decisions of one cell to those of its neighbours. Notch activation has a
profound effect on many aspects of nervous system development. Here we present a brief
overview of Notch signalling and reiterate some relevant questions relating to the Notch